IMPLEMENTATION NUTRIGENOMIC OF VITAMIN D IN PERIODONTITIS

Background: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on human genome, either directly or indirectly, can change expression and structure genes. One micronutrients associated with periodontitis vitamin D. Vitamin D has an important role in bone calcium metabolism regulates serum phosphate concentrations at normal limits. Purpose: To discuss nutritional as essential micronutrient preventing accelerating healing periodontitis. Review: Searched two databases from article publication to April 2021, resulting total 66 hits, which seven relevant articles were selected. VDR signaling build transcription genes encoding proactive cytokines, bypassing cyclo-oxygenase-2 (COX-2) prostaglandin pathway, inhibit matrix metalloproteinase production. The protective mechanism against occurs through biological pathways, namely anti-microbial anti-inflammatory pathways. effect results binding 1,25(OH)2D3 then induces cAMP, b-def-2 b-def-3 peptides by macrophages, monocytes, gingival epithelium ligament epithelium. decreased production proinflammatory cytokines. Conclusion: All effects reduce bacteria induced inflammatory cytokines so that personalized supplementation adjusted dose needed be used